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<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">目前临床指南将多发性骨髓瘤的诊治分为适合移植的患者和不适合移植的患者。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">对于不适合移植的患者，治疗方案主要选择含细胞毒性药物的新药联合化疗，细胞毒药物起效相对缓慢，但是缓解时间长，复发慢。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">对于适合移植的患者，临床上通常采取起效较快的靶向治疗，使患者尽快达到缓解后接受移植。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">在马法兰尚未进入国内的时期，适合移植的患者和不适合移植的患者治疗方案基本相似。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">目前马法兰已经进入国内，不适合移植的患者一线治疗主要采用马法兰联合硼替佐米的治疗方案。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">除此之外，</font><font face="Microsoft YaHei UI">VRd方案（</font></span></span></span></span><span style="color:#3498db;"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI"><u><strong>硼替佐米、来那度胺、地塞米松</strong></u></font></span></span></span></span><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">）也是多发性骨髓瘤的标准一线治疗方案。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">无论患者是否适合接受移植，一线治疗均可采用VRd方案。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">VRd方案对于部分老年、伴随疾病多的患者可能无法耐受，这部分患者可以选择</font></span></span></span></span><span style="color:#3498db;"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI"><u><strong>硼替佐米</strong></u></font></span></span></span></span><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">联合地塞米松或者</font></span></span></span></span><span style="color:#3498db;"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI"><u><strong>来那度胺</strong></u></font></span></span></span></span><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">联合地塞米松的两药联合方案。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p align="justify" class="p" style="margin-top:0.0000pt; margin-right:0.0000pt; margin-bottom:0.0000pt; margin-left:0.0000pt; padding:0pt 0pt 0pt 0pt ; text-align:justify; margin:5pt 0pt"><span style="font-size:12pt"><span style="background:#ffffff"><span style="text-justify:inter-ideograph"><span style="line-height:18.4000pt"><span style="font-family:Calibri"><span style="font-size:9.0000pt"><span style="background:#ffffff"><span style="font-family:'Microsoft YaHei UI'"><span style="color:#333333"><span style="letter-spacing:0.3500pt"><span style="text-transform:none"><span style="font-style:normal"><font face="Microsoft YaHei UI">此外，肾功能较差的患者不适合使用来那度胺，这部分患者可以选择硼替佐米、地塞米松联合细胞毒性药物（如环磷酰胺、多柔比星）的治疗方案。</font></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p><span style="color:null;">美国原厂的</span><font color="#3498db"><b><u>来那度胺</u></b></font>价格十分昂贵，让很多一般家庭都望而却步，<span style="color:#3498db;"><strong><u>仿制版的来那度胺</u></strong></span>在疗效上和原研几乎一致，价格低廉（<span style="color:#3498db;"><u><strong>来那度胺<u><strong><span style="background-color:null;">价</span></strong></u>格</strong></u></span>，<a href="http://kft.zoosnet.net/LR/Chatpre.aspx?id=KFT36340607&lng=cn" onclick="window.open(this.href, '', 'resizable=no,status=no,location=no,toolbar=no,menubar=no,fullscreen=no,scrollbars=no,dependent=no'); return false;"><span style="color:#ffffff;"><span style="background-color:#f39c12;">立即咨询</span></span></a>）成了大多数患者的最佳选择。</p>

<p>如果您有关于<font color="#3498db"><b><u>多发性骨髓瘤</u></b></font>临床治疗或靶向药<font color="#3498db"><b><u>来那度胺</u></b></font>方面的疑问，可直接致电鲸人医疗专家热线：18515676770/15321833786，<a href="http://kft.zoosnet.net/LR/Chatpre.aspx?id=KFT36340607&lng=cn" onclick="window.open(this.href, '', 'resizable=no,status=no,location=no,toolbar=no,menubar=no,fullscreen=no,scrollbars=no,dependent=no'); return false;"><span style="color:#ffffff;"><span style="background-color:#f39c12;">立即咨询</span></span></a></p>

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