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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">【用法用量】</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">推荐剂量：</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">推荐剂量是</font><font face="微软雅黑">800 mg，口服，每天1次，空腹给药(至少餐前1小时或餐后2小时)。帕唑帕尼的剂量不应超过800 mg。</font></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">【药物不良反应】</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">肝毒性</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">QT延长和尖端扭转型室速</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">出血事件</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">动脉血栓事件</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">胃肠道穿孔和瘘管</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">高血压</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">影响伤口愈合</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">甲状腺机能减退</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">腹泻</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">蛋白尿</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">脂肪酶升高</font></span></span></span></span></p>

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<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">【药物注意事项】</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">体外研究提示帕唑帕尼在人肝微粒体中的氧化代谢主要是通过</font><font face="微软雅黑">CYP3A4介导，次要贡献来自CYP1A2和 CYP2C8。所以，CYP3A4的抑制剂和诱导剂可能改变帕唑帕尼的代谢。</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">CYP3A4抑制剂：帕唑帕尼与CYP3A4的强抑制剂同时给药(如，酮康唑, 利托那韦, 克拉霉素)可能增加帕唑帕尼浓度。当必须与强CYP3A4抑制剂同时给药时应考虑减低帕唑帕尼剂量，如降低到400mg/d。应避免葡萄柚汁与药物同时服用，因它抑制CYP3A4活性和也可能增加帕唑帕尼的血浆浓度.</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">CYP3A4诱导剂：CYP3A4诱导剂例如利福可能减低血浆帕唑帕尼浓度。如不能避免使用强CYP3A4诱导剂，则不应使用帕唑帕尼。</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">孕妇和哺乳期妇女不应该服用该药物。</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri"><span style="font-size:10.5000pt"><span style="font-family:微软雅黑"><font face="微软雅黑">肾损伤患者，可以无需调整药物的服用剂量。</font></span></span></span></span></p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"> </p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify"> </p>

<p style="margin:0pt 0pt 0.0001pt; text-align:justify">原厂的<span style="color:#3498db;"><u><strong>帕唑帕尼</strong></u></span>价格昂贵，让很多患者望而却步，印度产的诺华原厂<font color="#3498db"><b><u>帕唑帕尼</u></b></font>，价格却十分低廉，因此成为绝大多数患者的不二之选。</p>

<p>如果您有关于肾癌治疗，<font color="#3498db"><b><u>帕唑帕尼</u></b></font>方面的疑问，可直接致电鲸人医疗专家热线：18515676770/15321833786，<a href="http://kft.zoosnet.net/LR/Chatpre.aspx?id=KFT36340607&lng=cn" onclick="window.open(this.href, '', 'resizable=no,status=no,location=no,toolbar=no,menubar=no,fullscreen=no,scrollbars=no,dependent=no'); return false;"><span style="color:#ffffff;"><span style="background-color:#f39c12;">立即咨询</span></span></a></p>

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